2025
Mob1 deletion in murine mature adipocytes ameliorates obesity and diabetes.
Nishio M, Yamaguchi K, Otani J, Yuguchi K, Kohno D, Sasaki T, Kitamura T, Shinohara M, Soga T, Kawamura K, Sasaki AT, Oshima M, Hikasa H, Woo M, Sasaki T, Nishina H, Nakao K, Maehama T, Suzuki A.*
Proc Natl Acad Sci U S A, Apr 29;122(17):e2424741122. doi: 10.1073/pnas.2424741122.
PMID:
Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy.
Asakura J, Nagao M*, Shinohara M, Hosooka T, Kuwahara N, Nishimori M, Tanaka H, Satomi-Kobayashi S, Matsui S, Sasaki T, Kitamura T, Otake H, Ishida T, Ogawa W, Hirata K, Toh R.
Cardiovasc Diabetol (2025) Apr 16;24(1):167. doi: 10.1186/s12933-025-02725-5.
PMID:
(+)-Terrein exerts anti-obesity and anti-diabcetic effects by regulating the differentiation and thermogenesis of brown adipocytes in mice fed a high-fat diet.
Aoki-Saito H, Mandai H, Nakakura T, Sasaki T, Kitamura T, Omori K, Hisada T, Okada S, Suga S, Yamada M, Saito T*.
Biomed Pharmacother (2025) Apr 4:186:118030. doi: 10.1016/j.biopha.2025.118030.
PMID:
Exposure to mouse dams to bonito broth during gestation or lactation reduces fat intake in offspring.
Fushimi S, Matsui S, Oguri Y, Tsuzuki S, *Sasaki T.
Appetite, 2025 Feb 1:206:107836. doi: 10.1016/j.appet.2024.107836.
PMID:
2024
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism.
Nomura K, Kinoshita S, Mizusaki N, Senga Y, Sasaki T, Kitamura T, Sakaue H, Emi A, Hosooka T, Matsuo M, Okamura H, Amo T, Wolf AM, Kamimura N, Ohta S, Itoh T, Hayashi Y, Kiyonari H, Krook A, Zierath JR, Kasuga M, Ogawa W.
Mol Metab, 2024 Aug:86:101968. doi: 10.1016/j.molmet.2024.101968.
PMID:
Medium-Chain Triglycerides-Specific Appetite is Regulated by the β-oxidation of Medium-Chain Fatty Acids in the Liver
Maruyama T, Matsui S, Kobayashi R, Horii T, Oguri Y, Tsuzuki S, Horie T, Ono K, Hatada I, *Sasaki T.
Am J Physiol Endocrinol Metab. 2024;326(5):E735-E746. doi: 10.1152/ajpendo.00031.
PMID:
Binding Interaction Between Lauric Acid and Cluster of Differentiation 36 Underpinned by a Fluorescence- Intensifying Assay
*Tsuzuki S, Sugawara T, Manabe Y, Yamasaki M, Sasaki T.
J Oleo Sci. 2024;73(1):113-119. doi: 10.5650/jos.ess23156.
PMID:
2023
A point of view on human fat olfaction - do fatty derivatives serve as cues for awareness of dietary fats?
*Tsuzuki S.
Biomed Res. 2023;44(4):127-146. doi: 10.2220/biomedres.44.127.
PMID:
2022
Application of a novel fluorescence intensity assay: identification of distinct fatty acetates as volatile compounds that bind specifically to amino acid region 149-168 of a transmembrane receptor CD36.
*Tsuzuki S, Kimoto Y, Marui K, Lee S, Inoue K, Sasaki T.
Biosci Biotechnol Biochem. 2022 Mar 21;86(4):509-518. doi: 10.1093/bbb/zbac018.
PMID:
Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium.
Kim TH, Young SL, Sasaki T, Deaton JL, Schammel DP, Palomino WA, Jeong JW, Lessey BA.
J Clin Endocrinol Metab. 2022 Feb 17 ;107(3):788-800. doi: 10.1210/clinem/dgab753.
PMID:
The Hypothalamic Paraventricular Nucleus Is the Center of the Hypothalamic-Pituitary-Thyroid Axis for Regulating Thyroid Hormone Levels.
Kondo Y, Ozawa A, Kohno D, Saito K, Buyandalai B, Yamada S, Horiguchi K, Nakajima Y, Shibusawa N, Harada A, Yokoo H, Akiyama H, Sasaki T, Kitamura T, Yamada M*.
Thyroid. 2022 Jan;32(1):105-114. doi: 10.1089/thy.2021.0444.
PMID:
2021
Assessment of direct binding interaction between CD36 and its potential lipid ligands using a peptide mimic of the receptor labeled with a fluorophore.
*Tsuzuki S, Kimoto Y, Yamasaki M, Sugawara T, Manabe Y, Inoue K, Sasaki T.
Biomed Res. 2021;42(5):181-191. doi: 10.2220/biomedres.42.181.
PMID:
Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.
Kawakami R, Matsui M, Konno A, Kaneko R, Shrestha S, Shrestha S, Sunaga H, Hanaoka H, Goto S, Hosojima M, Kabasawa H, Obokata M, Koitabashi N, Matsui H, Sasaki T, Saito A, Yanagita M, Hirai H, Kurabayashi M, Iso T.
J Pathol. 2021 Dec;255(4):362-373. doi: 10.1002/path.5775.
PMID:
Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice.
Wada E, Kobayashi M, Kohno D, Kikuchi O, Suga T, Matsui S, Yokota-Hashimoto H, Honzawa N, Ikeuchi Y, Tsuneoka H, Hirano T, Obinata H, Sasaki T, Kitamura T.
J Nutr Biochem. 2021 Jun 28;97:108811. doi: 10.1016/j.jnutbio.2021.108811.
PMID:
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.
Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Watanabe T, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, Nakashima Y, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K.
Nat Commun. 2021 Feb 16;12(1):843. doi: 10.1038/s41467-021-21107-5.
PMID:
2020
Blood-cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA.
Ngo-Thanh H, Sasaki T, Suzue K, Yokoo H, Isoda K, Kamitani W, Shimokawa C, Hisaeda H, Imai T.
Int J Parasitol. 2020 Dec;50(14):1167-1175. doi: 10.1016/j.ijpara.2020.07.007.
PMID:
Leukotriene A 4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.
Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Jo-Watanabe A, Kazuno S, Miyatsuka T, Kitamura T, Fujitani Y, Watada H, Saeki K, Yokomizo T.
FASEB J. 2020 Aug 26. doi: 10.1096/fj.202001148R.
PMID:
The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis.
Hosooka T, Hosokawa Y, Matsugi K, Shinohara M, Senga Y, Tamori Y, Aoki C, Matsui S, Sasaki T, Kitamura T, Kuroda M, Sakaue H, Nomura K, Yoshino K, Nabatame Y, Itoh Y, Yamaguchi K, Hayashi Y, Nakae J, Accili D, Yokomizo T, Seino S, Kasuga M, Ogawa W.
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11674-11684. doi: 10.1073/pnas.1921015117. Epub 2020 May 11.
PMID:
2019
Higher straight-chain aliphatic aldehydes: Importance as odor-active volatiles in human foods and issues for future research.
*Tsuzuki S.
J Agric Food Chem. 2019 May 1;67(17):4720-4725. doi: 10.1021/acs.jafc.9b01131.
PMID:
SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels.
Suga T, Kikuchi O, Kobayashi M, Matsui S, Yokota-Hashimoto H, Wada E, Kohno D, Sasaki T, Takeuchi K, Kakizaki S, Yamada M, Kitamura T.
Mol Metab. 2019 Jan;19:1-12. doi: 10.1016/j.molmet.2018.10.009.
PMID:
2018
Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice.
Matsui S, *Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T.
Nat Commun. 2018 Nov 2;9(1):4604. doi: 10.1038/s41467-018-07033-z.
PMID:
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance.
Gulshan M, Yaku K, Okabe K, Mahmood A, Sasaki T, Yamamoto M, Hikosaka K, Usui I, Kitamura T, Tobe K, Nakagawa T.
Aging Cell. 2018 Jun 14:e12798. doi: 10.1111/acel.12798. [Epub ahead of print]
PMID:
A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice.
*Sasaki T, Numano R, Yokota-Hashimoto H, Matsui S, Kimura N, Takeuchi H, Kitamura T.
Mol Brain. 2018 May 24;11(1):28. doi: 10.1186/s13041-018-0372-9.
PMID:
A role for scavenger receptor B1 as a captor of specific fatty acids in taste buds of circumvallate papillae.
*Tsuzuki S, Lee S, Kimoto Y, Sugawara T, Manabe Y, Inoue K.
Biomed Res. 2018;39(6):295-300. doi: 10.2220/biomedres.39.295.
PMID:
A novel role for scavenger receptor B1 as a contributor to the capture of specific volatile odorants in the nasal cavity.
*Tsuzuki S, Kimoto Y, Lee S, Sugawara T, Manabe Y, Inoue K.
Biomed Res. 2018;39(3):117-129. doi: 10.2220/biomedres.39.117.
PMID:
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