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Title
Measurement of hormones that is generated by the ingestion of medium-chain triglycerides (approval number R5064).
Ethical Approval
The current study is approved by the Ethics Committee of Kyoto University Graduate School and Faculty of Medicine.
Name of the institution and the person responsible
Tsutomu Sasaki at Graduate School of Agriculture, Kyoto University
Dr. Andreas M. Fritzen at Copenhagen University (collaborator)
Aims and Scopes of the research
We have identified a novel hormone in mice that is generated by the ingestion of medium-chain triglycerides (MCTs) and its metablism. To test if the hormone is also generated in humans by the same mechanism, we will measure the concentration of the hormones in the blood samples obtained from patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency and healthy individuals after the ingestion of either MCTs or long-chain triglycerides (LCTs).
The samples and information obtained under the clinical trial conducted in Denmark entitled "Metabolic Effects of Medium-Chain Fatty Acids in Patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals (MEMCADD)," which is registered at ClinicalTrials.gov as will be used.
Elucidating the dynamics of this hormone in humans will help to validate if this hormone would become a candidate for drug development targeting appetite and metabolism, which would help to address life-style related diseases.
Study period
From August 7, 2025 to December 31, 2026.
Information and samples used
We will use serum samples and information to identify whether sample is obtained from healthy vs. MEMCADD patients, and when the samples were obtained, and after which type of triglyceride ingestion (MCT or LCT).
Opting out from the study
If you are a participant of the above research conducted in Denmark and would like to opt out from the measurement of the hormone that we have identified, please contact Tsutomu Sasaki at the following contact information. We will remove you from the analysis.
Email: sasaki.tsutomu.5m(##)kyoto-u.ac.jp (please change ## to @)
Phone: +81-(0)75-753-6263
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Tsutomu Sasaki, MD/PhD, Professor of Nutrition Chemistry
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